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Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University in Boston have found that people who consume whole grain-based diet as against a refined grain-based diet show modest improvement in stool, gut microbiota and immune response.
While unfolding the results of the study, Simin Nikbin Meydani, director of the nutritional immunology laboratory said, “The strength of the study is that we found modest effects of whole grain on gut microbiota and measures of immune function in the context of a controlled energy and macronutrient diet.”
For the purpose of the study, researchers looked at 81 participants. While 40 were administered refined grain diet, 41 were given the whole grain diet.
The program continued for 8 weeks – two weeks of run-in period followed by six weeks of consuming the fully provided diet.
At the end of the trial researchers found decreasing Enterobacteriaceae abundance and increased presence of Lachnospira and Roseburia abundance in the participants consuming the whole grain diet.
Researchers also noted a modest positive correlation between TNF-alpha and total alkylresorcinols clearly linked to increased whole grain intake.
The team lead by Meydani advocated the intake of whole grain diet and suggested that this kind of diet can have a clear and greater impact on patients already diagnosed with inflammatory conditions.